Benfotiamine 300mg

Description

Benfotiamine 300mg to a capsule, 60 servings, about 38 cents each. Benfotiamine is S-benzoylthiamine O-monophosphate, a lipid soluble derivative of thiamine, which is vitamin B1. The reason it is sold separately from ordinary thiamine is a pharmacokinetic one rather than a nutritional one, and the comparison between a benfotiamine 300mg capsule and 300 mg of thiamine hydrochloride is the whole point of the product.

What is in the capsule

Benfotiamine 300mg against plain thiamine, in the published data

Comparative bioavailability studies gave equal milligram doses of benfotiamine and thiamine hydrochloride and measured plasma thiamine concentrations and erythrocyte transketolase activity, with the lipid soluble form returning the higher readings. Clinical work using this compound has generally run 300 to 600 mg a day, often as 300 mg two or three times daily, with endpoints including nerve conduction measurements and symptom questionnaires. Those are the doses administered and the instruments read in the literature. They are not claims about this bottle.

Put the 300 mg figure next to the intake reference of just over 1 mg a day and the scale is obvious. Products at this level are not being sold as a way to meet a daily requirement, and the NIH thiamin fact sheet sets out what the requirement actually is, along with the food sources that cover it.

Benfotiamine 300mg and the other fat soluble thiamine forms

Benfotiamine is the one with the research record, and it is not the only lipid soluble derivative on the market. Sulbutiamine and fursultiamine are the others, each with its own literature and its own dose range, and none of the three is interchangeable with the others on a milligram basis. A label reading fat soluble B1 without naming the compound has told you nothing you can verify. This one names it and the certificate measures it.

Why a benfotiamine 300mg capsule is sold at all

Thiamine absorption from the water soluble form is limited by an active transport mechanism that saturates, so taking a great deal more of it does not raise blood concentrations proportionally. That constraint is why lipid soluble derivatives were developed in the first place, and why a benfotiamine 300mg capsule sits on the shelf next to a 100 mg thiamine tablet at a similar price. The difference between them is pharmacokinetic. Whether it matters for you is a question for a clinician, not for a product page.

Why the form is named on the front

Our vitamins page names the chemical form on every label rather than leaving a generic letter, because the forms behave differently in measurable ways. Cyanocobalamin and methylcobalamin are both B12. Pyridoxine hydrochloride and P-5-P are both B6. Thiamine hydrochloride and benfotiamine are both B1, and the second is the only one of the three pairs where the difference is about fat solubility rather than methylation.

Not a substitute for thiamine in a multivitamin

A benfotiamine 300mg bottle is a single ingredient product at a high multiple of the daily reference. It is not a B complex and there is no magnesium, riboflavin or folate in it. If what you want is the vitamin at nutritional amounts in its active forms, the methylated B complex is the item to look at instead. The two are priced very differently per milligram, and the figure under each price makes that comparison immediate.

Testing

Every lot of benfotiamine 300mg is identity tested and assayed by a laboratory with no ownership tie to us, with heavy metals, residual solvents and microbials on the same certificate, since this is a synthesised compound rather than a plant extract. Under strength lots are withdrawn and the failing report stays published, as explained in why we publish the batch that failed. Your certificate is linked above.